• members of E3 complexes
  • yeast Der1p: multi-pass transmembrane protein that interacts with Hrd1p and Hrd3p as well as with substrates
  • dispensable for degradation of many substrates
  • contain a motif shared with rhomboid proteases (which recognize and cleave protein sequences within the membrane using hydrophilic residues within their TM domains); lack catalytic sites
  • luminal ERAD substrates are typically more dependent on Derlins

  • m

Ad blocker interference detected!

Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers

Wikia is not accessible if you’ve made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected.