Derlin (Der1p, DER1)

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  • members of E3 complexes
  • yeast Der1p: multi-pass transmembrane protein that interacts with Hrd1p and Hrd3p as well as with substrates
  • dispensable for degradation of many substrates
  • contain a motif shared with rhomboid proteases (which recognize and cleave protein sequences within the membrane using hydrophilic residues within their TM domains); lack catalytic sites
  • luminal ERAD substrates are typically more dependent on Derlins

  • m

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