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Welcome to the ERAD WikiEdit

ERAD

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  • new page Wiki Content
    created by SilfaZ
    New page: EDEMs:Edit 1184;mso-padding-alt:0in 5.4pt 0in 5.4pt;mso-border-insideh:none;mso-border-insidev: none" · in mammalian cells there are...
    Added photo:
  • edit ERAD substrates
    edited by SilfaZ diff
  • new page Doa10 (Doa10p)
    created by SilfaZ
    New page: Add a photo E3 ubiquitin ligase complex for substrates with misfolded cytosolic domains only other ERAD-active E3 in yeast besides Hrd1p Has broad...
  • edit HRD1
    edited by SilfaZ diff
  • edit ERdj5
    edited by SilfaZ diff
  • new page Htm1 (Htm1p)
    created by SilfaZ
    New page: Add a photo Htm1p forms a disulfide-stabilized complex with Pdi1p which is necessary for both maximal Htm1p activity as well as its stability (Gauss...
  • new page ERdj5
    created by SilfaZ
    New page: Add a photo interacts with EDEM1 can reduce disulfide bonds of aberrantly linked proteins accelerates ERAD when overexpressed (Ushioda et al.,...
  • new page HMG-CoA reductase (Hmg2p)
    created by SilfaZ
    New page: Add a photo yeast HMG-CoA reductase (Hmg2p) is the rate limiting enzyme in cholesterol synthesis example of physiological regulation of protein...
  • new page Derlin (Der1p, DER1)
    created by SilfaZ
    New page: Add a photo Function: members of E3 complexes yeast Der1p: multi-pass transmembrane protein that interacts with Hrd1p and Hrd3p as well as with...
  • new page UPR (unfolded protein response)
    created by SilfaZ
    New page: Add a photo Definition: UPR orchestrates increased expression of key ERAD components in metazoans, different arms of the UPR up-regulate distinct...

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